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What is the likelihood of a flu pandemic

The evolution of flu viruses cannot be predicted. This makes it difficult to know if or when a virus might mutate to become easily transmittable among humans. Therefore, it is impossible to say when another pandemic will arise, or whether it will be mild or severe.
 
However, the World Health Organisation (WHO) asserts that once a virus allows for efficient human-to-human transmission, a pandemic can occur. Because of high global mobility and interconnection, illness could spread quickly and, if the virus has a high fatality rate, threaten millions of lives around the world. 10

A lesson from the past

Pandemics are a reality. Although there is some debate amongst experts, health records show at least 7 - 10 influenza pandemics over the past 300 years.24,25

Dates of Pandemics in the past 300 years:

 YearDocumented Geographical Impact
1729 - 1730Origin Russia, spreading westward to all Europe
1781 - 1782Origin China, spreading to Russia, all of Europe and USA
1830 - 1833Origin China, spreading southwards to India, SE Asia and eventually Europe and USA
1898 - 1900Origin unknown
1918 - 1920 Origin unknown, global impact 
1957 - 1958Origin China, spreading to Southern Hemisphere and then Northern Hemisphere the following winter
1968 - 1969Origin Hong Kong